Background：IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens.
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.
May function in skin immunity.
IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.
IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.
These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
仕様
サイズ：25ug
Source：Biotinylated Mouse IL-31, His,Avitag (IL1-M82Q9) is expressed from human 293 cells (HEK293). It contains AA Thr 24 - Cys 163 (Accession # Q6EAL8-1).
Molecule：IL-31
Synonyms：IL-31,IL31,Interleukin-31
Species：Mouse
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Thr 24 - Cys 163
Conjugate：Precision Avi
Accession：NP_083870.1
Molecular Weight：19.2 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 19.2 kDa. The protein migrates as 20-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
