Background：Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family.
IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses.
It binds to the interleukin-1 receptor.
IL-1α is constitutively produced by epithelial cells.
It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body.
In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range.
In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.
仕様
サイズ：100ug
Source：Human IL-1 alpha, His Tag (ILA-H5216) is expressed from human 293 cells (HEK293). It contains AA Ser 113 - Ala 271 (Accession # P01583-1).
Molecule：IL-1 alpha
Synonyms：IL1A,IL-1 ALPHA,IL1F1,IL1α
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ser 113 - Ala 271
Conjugate：Unconjugated
Accession：NP_000566.3
Molecular Weight：19.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.9 kDa. The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
