Background：Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins.
Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain.
CTGF promotes proliferation and differentiation of chondrocytes.
Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells.
Enhances fibroblast growth factor-induced DNA synthesis.
Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
仕様
サイズ：100ug
Source：Human CTGF, Fc Tag (GTF-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln27-Ala349 (Accession # Q5M8T4-1 ).
Molecule：CTGF
Synonyms：CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Gln27-Ala349
Conjugate：Unconjugated
Accession：NP_001892.1
Molecular Weight：61.9 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 61.9 kDa. The protein migrates as 55-60 kDa and 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
