Background：USAG1 (uterine sensitization associated gene 1), also known asSOSTDC1 (sclerostin domain–containing 1), Ectodin, is a secreted protein with a glycosylated N-terminus that contains a C-terminal cysteine knot domain.
This C-terminal cysteine knot domain is present in numerous growth factors, including TGFβ, NGF, PDGF, vWF, NDP, and mucin-2, and involved in dimerization, receptor binding, and signal transduction.
SOSTDC1 negatively regulates BMP signaling during cellular proliferation, differentiation, and apoptosis in several biological processes (such as dentary morphogenesis, embryo implantation in the endo-metrium, and healing of bone fractures) [8].
In addition, SOSTDC1 might also involve cancer development processes through the regulation of the Wnt pathway.
仕様
サイズ：100ug
Source：Human USAG-1, Fc Tag (US1-H5254) is expressed from human 293 cells (HEK293). It contains AA Phe 24 - Ser 206 (Accession # Q6X4U4-1).
Molecule：USAG-1
Synonyms：Uterine sensitization-associated gene 1 protein
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Phe 24 - Ser 206
Conjugate：Unconjugated
Accession：NP_056279.1
Molecular Weight：47.2 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 47.2 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
