86-7932-76　［取扱停止］Cynomolgus IL-1 beta / IL-1F2 Protein, His Tag 50ug　ILB-C51H3

特徴

• Background：Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene.
• IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase).
• Cytosolic thiol protease cleaves the product to form mature IL-1 beta.
• IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human.
• Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins.
• While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects.
• IL-1β is a member of the interleukin 1 cytokine family.
• This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).
• This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
• The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
• This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.