Background：Netrins control guidance of CNS commissural axons and peripheral motor axons.
Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively.
Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion.
Involved in dorsal root ganglion axon projection towards the spinal cord.
It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis.
Involved in tumorigenesis by regulating apoptosis.
仕様
サイズ：100ug
Source：Human Netrin-1, His Tag (NE1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 604 (Accession # O95631-1).
Molecule：Netrin-1
Synonyms：Netrin-1,NTN1,NTN1L,Netrin1,netrin 1
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Val 22 - Ala 604
Conjugate：Unconjugated
Accession：NP_004813.2
Molecular Weight：67.5 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 67.5 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
