Background：Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway.
Krm1 and its paralog Krm2 share the ability to bind Dkk1 and inhibit Wnt signaling, both processes previously shown to rely on the extracellular domain.
Previous studies have shown that Krm2 may be involved in embryonic development, bone formation, neural ridge formation and tumorigenesis and could be a biomarker of grading and a potential therapeutic target in gastric cancer.
仕様
サイズ：100ug
Source：Human Kremen-2, His Tag (KR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Ala 364 (Accession # Q8NCW0-1).
Molecule：KREMEN2
Synonyms：KREMEN2, Kremen-2, KRM2, Dickkopf receptor 2,Kringle domain-containing transmembrane protein 2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gly 26 - Ala 364
Conjugate：Unconjugated
Accession：NP_757384.1
Molecular Weight：38.0 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.0 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
