Background：Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
仕様
サイズ：100ug
Source：Human Mucin-1 (116-173), Fc Tag (MU1-H5153) is expressed from E.coli cells. It contains AA Ser 116 - Gly 173 (Accession # P15941-8).
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32.7 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
