Background：B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
仕様
サイズ：100ug
Source：Mouse CD79B, His Tag (CDB-M52H3) is expressed from human 293 cells (HEK293). It contains AA Val 26 - Asp 158 (Accession # P15530-1).
Molecule：CD79B
Synonyms：CD79b,B29,IGB,Ig-beta
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Val 26 - Asp 158
Conjugate：Unconjugated
Accession：NP_032365.1
Molecular Weight：17.0 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.0 kDa. The protein migrates as 28-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
