Background：Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii).
CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein.
The cell surface form of the invariant chain is known as CD74.
CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation.
CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place.
CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
仕様
サイズ：100ug
Source：Human CD74, Fc Tag (CD4-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 73 - Met 232 (Accession # P04233-2).
Characteristics：This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
