86-7932-03 ［取扱停止］Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (MALS verified) 100ug ILF-H52W6
特徴
- Background：Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells.
- IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases.
- Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms.
- High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仕様
- サイズ：100ug
- Source：Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (ILF-H52W6) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (IL-17A) & Arg 31 - Gln 163 (IL-17F) (Accession # Q16552-1 (IL-17A) & Q96PD4-1 (IL-17F)). Two sequential affinity purification steps were used to ensure exact 1:1 molar ratio of IL17A＆IL17F heterodimer.
- Molecule：IL-17A & IL-17F
- Synonyms：IL-17A,Interleukin-17A,CTLA-8,IL-17,IL-17F,Interleukin-17F,Cytokine ML-1
- Species：Human
- Tag：His Tag & Strep Tag
- Expression Systems：HEK293
- Expression Rigeion：Gly 24 - Ala 155 (IL-17A) & Arg 31 - Gln 163 (IL-17F)
- Conjugate：Unconjugated
- Accession：NP_002181.1 (IL-17A) & NP_443104.1 (IL-17F)
- Molecular Weight：18.5 kDa ∣ 16.8 kDa
- Characteristics：Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag, produced by co-expression of IL-17A and IL-17F, has a calculated MW of 18.5 kDa (IL-17A) and 16.8 kDa (IL-17F). Subunit IL-17A is fused with a Twin Strep tag at the N-terminus and subunit IL-17F is fused with a polyhistidine tag at the N-terminus. The reducing (R) protein migrates as 19-27 kDa due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：100ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7932-02
Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (MALS verified) 20ug
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86-7932-03
Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (MALS verified) 100ug
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