Background：Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho.
FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D.
Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes.
FGF23 and phosphate have been revealed to be factors relevant in cancer.
FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.
仕様
サイズ：100ug
Source：Human FGF-23 (R179Q), His Tag (FG3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 251 (Accession # Q9GZV9-1 (R179Q)).
Molecule：FGF-23
Synonyms：FGF23,HYPF,FGF-23,ADHR,HPDR2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Tyr 25 - Ile 251
Conjugate：Unconjugated
Accession：NP_065689.1
Molecular Weight：27.3 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.3 kDa. The protein migrates as 30-32 kDa and 33-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：20 mM MOPS, 150 mM NaCl, 5 mM EDTA, 2 mM DTT, pH7.4
