Background：CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production.
BCR complexes are composed of a ligand-binding receptor (membrane immunoglobulin; mIg), non-covalently associated with the signaling com-ponent, a disulfide-linked heterodimer of CD79a (Igα) and CD79b (Igβ).
Both CD79 subunits consist of an Ig-like domain, a transmembrane (TM) region, and a longer cytoplasmic tail (CYT) containing an immune-receptor tyrosine-based activation motif (ITAM).
仕様
サイズ：100ug
Source：Human CD79A&CD79B Heterodimer Protein, Mouse IgG2a Fc,Flag Tag&Mouse IgG2a Fc,His Tag (CDB-H52W3) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Arg 143 (CD79A) & Ala 29 - Asp 159 (CD79B) (Accession # P11912-1 (CD79A) & P40259-1 (CD79B)).
Molecule：CD79A & CD79B
Synonyms：CD79A&CD79B, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain
Species：Human
Expression Systems：HEK293
Expression Rigeion：Leu 33 - Arg 143 (CD79A) & Ala 29 - Asp 159 (CD79B)
Conjugate：Unconjugated
Accession：NP_001774.1 | NP_000617.1
Molecular Weight：43.8 kDa | 46.7 kDa
Characteristics：Human CD79A&CD79B Heterodimer Protein, Mouse IgG2a Fc,Flag Tag&Mouse IgG2a Fc,His Tag is produced by co-expression of CD79A and CD79B, has a calculated MW of 43.8 kDa (CD79A) and 46.7 kDa (CD79B). Subunit CD79A carries a mouse IgG2a Fc fragment at the C-terminus, followed by a flag tag and subunit CD79B carries a mouse IgG2a Fc fragment at the C-terminus, followed by a polyhistidine tag. The non-reducing (NR) protein migrates as 115-120 kDa due to glycosylation.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
