Background：Cyr61，also know as Cellular communication network factor 1（CCN1）can promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion.
Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5.
CCN1-mediated gene regulation is dependent on heparin-binding.
Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1.
Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
仕様
サイズ：25ug
Source：Biotinylated Human Cyr61/CCN1 Protein, His,Avitag (CY1-H82H5) is expressed from human 293 cells (HEK293). It contains AA Gln 29 - Ala 248 (Accession # O00622-1).
Molecule：Cyr61
Synonyms：CCN family member 1,CCN1,CCN1IGF-binding protein 10,Cyr61,Cysteine-rich angiogenic inducer 61,cysteine-rich,angiogenic inducer,61,GIG1,GIG1cysteine-rich heparin-binding protein 61,IBP-10,IGFBP-10,IGFBP10cysteine-rich, anigogenic inducer, 61,Insulin-like g
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gln 29 - Ala 248
Conjugate：Precision Avi
Accession：NP_001545.2
Molecular Weight：43.0 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 43.0 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
