Background：TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively.
Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes.
DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells.
Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines.
Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.
仕様
サイズ：100ug
Source：Human TL1A, His Tag (TLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 72- Leu 251 (Accession # O95150-1).
Molecule：TL1A
Synonyms：TL1A, VEGI-251, TNFSF15
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Leu 72- Leu 251
Conjugate：Unconjugated
Accession： NP_005109.2
Molecular Weight：22.4 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
