Background：Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes.
CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst.
One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues.
The active site of most carbonic anhydrases contains a zinc ion.
There are at least five distinct CA families (α, β, γ, δ and ε).
Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family.
CA9 / CAIX with an optimal activity at pH 6.49.
Reversible hydration of carbon dioxide.
CA IX participates in pH regulation.
CA9 may be involved in the control of cell proliferation and transformation.
CA-IX appears to be a novel specific biomarker for a cervical neoplasia.
仕様
サイズ：50ug
Source：Mouse Carbonic Anhydrase IX (32-390), His Tag (CA9-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Asp 390 (Accession # Q8VHB5-1).
Molecule：Carbonic Anhydrase IX
Synonyms：CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 32 - Asp 390
Conjugate：Unconjugated
Accession：NP_647466.2
Molecular Weight：40.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.7 kDa. The protein migrates as 46-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
