Background：Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.
Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.
Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.
Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
This chaperone activity is important to sustain normal SNARE-complex assembly during aging.
Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
仕様
サイズ：25ug
Source：Biotinylated Human Alpha-Synuclein, His,Avitag (ALN-H82H8) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
Molecule：Alpha-Synuclein
Synonyms：SNCA,NACP,PARK1,alpha-Synuclein
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：E.coli
Expression Rigeion：Met 1 - Ala 140
Conjugate：Precision Avi
Accession：NP_000336.1
Molecular Weight：18.0 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 18.0 kDa. The protein migrates as 23 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
