Background：CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen.
CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn.
CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency.
It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
仕様
サイズ：100ug
Source：Human CD45, His Tag (CD5-H52H8) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Lys 577 (Accession # P08575-3).
Molecule：CD45
Synonyms：CD45,PTPRC,L-CA,T200
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 26 - Lys 577
Conjugate：Unconjugated
Accession：NP_002829.3
Molecular Weight：62.8 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.8 kDa. The protein migrates as 120-170 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
