Background：The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling.
ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
仕様
サイズ：100ug
Source：Human ZNRF3, His Tag (ZN3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Lys 56 - Met 219 (Accession # Q9ULT6-1).
Molecule：ZNRF3
Synonyms：ZNRF3, Zinc,RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Lys 56 - Met 219
Conjugate：Unconjugated
Accession：NP_001193927.1
Molecular Weight：19.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
