Background：Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors.
GDF-2 Potent circulating inhibitor of angiogenesis.
Signals through the type I activin receptor ACVRL1 but not other Alks.
Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs).
BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells.
Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
仕様
サイズ：50ug
Source：Human GDF-2, Tag Free (GD2-H5211) is expressed from human 293 cells (HEK293). It contains AA Ser 320 - Arg 429 (Accession # Q9UK05-1).
Molecule：GDF-2
Synonyms：GDF-2,GDF2,BMP-9,BMP9
Species：Human
Tag：Tag Free
Expression Systems：HEK293
Expression Rigeion：Ser 320 - Arg 429
Conjugate：Unconjugated
Molecular Weight：12.1 kDa
Characteristics：This protein carries no "tag". The protein has a calculated MW of 12.1 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
