Background：Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
仕様
サイズ：100ug
Source：Cynomolgus Mucin-1, Fc Tag (MU1-C5252) is expressed from human 293 cells (HEK293). It contains AA Leu 254 - Gly 373 (Accession # XP_005541632.1).
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus.The mature Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved N-terminal fragment and C-terminal fragment. Each N-terminal fragment and C-terminal fragment has a calculated MW of 7.2 kDa and 32.8 kDa. The protein migrates as 48 kDa (precursor protein) and 40-45 kDa (C-terminus) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
