Background：Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development.
Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development.
Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development.
Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts.
Phosphorylates PLCG1, FRS2 and PAK4.
Ligand binding leads to the activation of several signaling cascades.
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.
FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.
Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling.
Over-expressed FGFR2 promotes activation of STAT1.
仕様
サイズ：100ug
Source：Human FGFR2 (IIIc), His Tag (FGC-H5225) is expressed from human 293 cells (HEK293). It contains AA Pro 154 - Thr 358 (Accession # P21802-1).
Molecule：FGF R2 (IIIc)
Synonyms：FGF R2 (IIIc),FGFR2B,FGFR2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Pro 154 - Thr 358
Conjugate：Unconjugated
Molecular Weight：24.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 38-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
