Background：Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6).
Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates.
Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD).
仕様
サイズ：100ug
Source：Human Kremen-1, Fc Tag (KR1-H5253) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Thr 392 (Accession # Q96MU8-1).
Molecule：KREMEN1
Synonyms：KREMEN, KRM1，Dickkopf receptor,Kringle domain-containing transmembrane protein 1,Kringle-containing protein marking the eye and the nose
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Arg 21 - Thr 392
Conjugate：Unconjugated
Molecular Weight：67.4 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
