Background：TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily.
TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity.
This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction.
Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
仕様
サイズ：100ug
Source：Human TGF-beta RII, His Tag (TG2-H52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Asp 159 (Accession # P37173-1).
Molecule：TGF-beta RII
Synonyms：TGFBR2,TGFR2,TbetaR-II,TGFβR2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Thr 23 - Asp 159
Conjugate：Unconjugated
Accession：NP_003233.4
Molecular Weight：17.4 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.4 kDa. The protein migrates as 25-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
