Background：NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH.
Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1.
The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ.
The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.
Involved in the maturation of both CD4+ and CD8+ cells in the thymus.
Important for follicular differentiation and possibly cell fate selection within the follicle.
During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
仕様
サイズ：100ug
Source：Human NOTCH1, Fc Tag (NO1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Gln 526 (Accession # P46531-1).
Molecule：NOTCH1
Synonyms：NOTCH1,Notch 1,hN1,TAN1
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ala 19 - Gln 526
Conjugate：Unconjugated
Accession：NP_060087.3
Molecular Weight：80.0 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.0 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
