Background：Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40).
IL-12 is involved in the differentiation of naive T cells into Th1 cells.
It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells.
It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ.
IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.
IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
仕様
サイズ：25ug
Source：Biotinylated Human IL-12B&IL-12A Heterodimer Protein, His,Avitag&Flag Tag (IL2-H8210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A) (Accession # P29460-1 (IL12B) & P29459-1 (IL12A)).
Molecule：IL-12B & IL-12A
Synonyms：IL12,p70,Interleukin-12
Species：Human
Tag：His Tag & Avi Tag & Flag Tag
Expression Systems：HEK293
Expression Rigeion：Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A)
Conjugate：Precision Avi
Molecular Weight：38.3 kDa | 23.8 kDa
Characteristics：Biotinylated Human IL-12B&IL-12A Heterodimer Protein, His,Avitag&Flag Tag is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 38.3 kDa (IL-12B) and 23.8 kDa (IL-12A). Subunit IL-12B is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag) and subunit IL-12A is fused with flag tag at the C-terminus. The reducing (R) heterodimer protein migrates as 40-50 kDa (IL12B) and 32-35 kDa (IL12A) respectively due to glyosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
