Background：Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells.
IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases.
Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms.
High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仕様
サイズ：100ug
Source：Cynomolgus IL-17A, His Tag (ILA-C5249) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (Accession # G7P4U9-1).
Molecule：IL-17A
Synonyms：IL-17A,Interleukin-17A,CTLA-8,IL-17
Species：Cynomolgus
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gly 24 - Ala 155
Conjugate：Unconjugated
Molecular Weight：17.0 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.0 kDa. The protein migrates as 18-19 kDa,24-25 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
