Background：Toll-like receptor 3 (TLR3) is also known as CD283, which belongs to the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms.
TLR3 / CD283 contains 22 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain and 1 TIR domain.
TLR3 is expressed at high level in placenta and pancreas and also detected in CD11c+ immature dendritic cells.
CD283 / TLR3 is only expressed in dendritic cells.
TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
CD283 / TLR-3 is the key component of innate and adaptive immunity.
TLR3 / CD283 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.
TLR3 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Defects in TL-R3 are associated with herpes simplex encephalitis type 2 (HSE2).
仕様
サイズ：100ug
Source：Human TLR3, Fc Tag (TL3-H5253) is expressed from human 293 cells (HEK293). It contains AA Ser 23 - Glu 703 (Accession # Q6PCD4-1).
Molecule：TLR3
Synonyms：TLR3,CD283,IIAE2
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ser 23 - Glu 703
Conjugate：Unconjugated
Molecular Weight：103.8 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 103.8 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
