Background：IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens.
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.
May function in skin immunity.
IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.
IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.
These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
仕様
サイズ：100ug
Source：Human IL-31, His Tag (IL1-H5247) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Thr 164 (Accession # Q6EBC2-1).
Molecule：IL-31
Synonyms：IL-31,IL31,Interleukin-31
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ser 24 - Thr 164
Conjugate：Unconjugated
Accession：NP_001014358.1
Molecular Weight：17.7 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.7 kDa. The protein migrates as 23-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
