Background：Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family.
There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24).
IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.
IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover.
IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis.
Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).
仕様
サイズ：100ug
Source：Mouse IL-17F, His Tag (ILF-M5249) is expressed from human 293 cells (HEK293). It contains AA Arg 29 - Ala 161 (Accession # Q7TNI7-1).
Molecule：IL-17F
Synonyms：IL-17F,Interleukin-17F,Cytokine ML-1
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Arg 29 - Ala 161
Conjugate：Unconjugated
Molecular Weight：16.8 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 16.8 kDa. The protein migrates as 24-25 kDa and 27-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
