Background：Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).
It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.
Tyk2 functions primarily in IL-12 and type I-IFN signaling.
Tyk2 deficiency has more dramatic effects in human cells than in mouse cells.
However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.
Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2.
Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
仕様
サイズ：50ug
Source：Human Tyk2, His Tag (TY2-H5549) is expressed from Baculovirus-Insect cells. It contains AA Asn 575 - Leu 869 (Accession # P29597-1).
Molecule：Tyk2
Synonyms：Tyk2,tyrosine kinase 2
Species：Human
Tag：His Tag
Expression Systems：InsectCells
Expression Rigeion：Asn 575 - Leu 869
Conjugate：Unconjugated
Molecular Weight：35.0 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.0 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
