Background：Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells.
Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5).
Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment.
Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
仕様
サイズ：100ug
Source：Cynomolgus TSLP, His Tag (TSP-C52H8) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # A0A7N9CAT7-1).
Molecule：TSLP
Synonyms：TSLP
Species：Cynomolgus
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Tyr 29 - Gln 159
Conjugate：Unconjugated
Accession：XP_005557555.1
Molecular Weight：11.7 kDa and 5.4 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus.This protein contains a furin convertase cleavage site, 127-RRKR-130, and will be processed into N and C-terminal fragment with calculated MW of 11.7 kDa and 5.4 kDa respectively. The protein migrates as 21 kDa, 15 kDa and 8 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
