Background：Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily.
ACVR1B contains one GS domain and one protein kinase domain.
The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”.
ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals.
Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B.
These go on to recruit the R-SMADs SMAD2 or SMAD3.
ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
仕様
サイズ：100ug
Source：Human Activin RIB, His Tag (ACB-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Glu 126 (Accession # P36896-1).
Molecule：Activin RIB
Synonyms：ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ser 24 - Glu 126
Conjugate：Unconjugated
Accession：AAH00254
Molecular Weight：13.3 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
