86-7929-82 ［取扱停止］Human Alpha-Synuclein Protein, His Tag 1mg ALN-H52H8
特徴
- Background：Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.
- Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.
- Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.
- Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
- This chaperone activity is important to sustain normal SNARE-complex assembly during aging.
- Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
仕様
- サイズ：1mg
- Source：Human Alpha-Synuclein, His Tag (ALN-H52H8) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
- Molecule：Alpha-Synuclein
- Synonyms：SNCA,NACP,PARK1,alpha-Synuclein
- Species：Human
- Tag：His Tag
- Expression Systems：E.coli
- Expression Rigeion：Met 1 - Ala 140
- Conjugate：Unconjugated
- Accession：NP_000336.1
- Molecular Weight：16.3 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：100 mM NaAC, pH7.0
- Package Size：1mg*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7929-82
Human Alpha-Synuclein Protein, His Tag 1mg
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86-7929-81
Human Alpha-Synuclein Protein, His Tag 200ug
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