Background：ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family.
ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain.
Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen.
B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS.
B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells.
B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
仕様
サイズ：100ug
Source：Cynomolgus B7-H2, Fc Tag (B72-C525b) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Thr 256 (Accession # XP_005548617.1).
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.0 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
