Background：Integrin alpha-1/beta-1 is a receptor for laminin and collagen.
The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis.
It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
仕様
サイズ：100ug
Source：Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wb) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1) (Accession # P56199-1 (ITGA1) & P05556-1 (ITGB1)).
Molecule：Integrin alpha 1 beta 1
Synonyms：Integrin alpha 1 beta 1,ITGA1&ITGB1
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1)
Characteristics：Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 130.0 kDa (ITGA1) and 83.7 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein migrates as 170-200 kDa (ITGA1) and 100-130 kDa (ITGB1) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
