Background：Coagulation factor XI is also known as F11, PTA and FXI.
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with high molecular weight kininogen.
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Factor XI is converted into XIa via either the contact phase of blood coagulation or thrombin-mediated activation on the platelet surface.
The resulting XIa converts factor IX into IXa, which subsequently activates factor X into Xa.
仕様
サイズ：50ug
Source：Human Coagulation factor XI, His Tag (FXI-H52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 19 - Val 625 (Accession # P03951-1).
Molecule：Coagulation factor XI
Synonyms：Coagulation factor XI,FXI,PTA,F11
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Glu 19 - Val 625
Conjugate：Unconjugated
Molecular Weight：69.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The proprotein is activated by factor XIIa (or XII) and cleaved after Arg-387 into the light chain with calculated MW of 28.7 kDa, which contains the active site, and the heavy chain with calculated MW of 41.2 kDa. The protein migrates as 47 kDa (heavy chain) and 35 kDa (light chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
