Background：Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor.
Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin.
Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.
In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.
仕様
サイズ：100ug
Source：Human HGF, His Tag (HGF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728 (Accession # P14210-1).
Molecule：HGF
Synonyms：HGF,HPTA,SF
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 32 - Ser 728
Conjugate：Unconjugated
Molecular Weight：81.6 kDa (53.7 kDa|27.9 kDa)
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The mature form of HGF is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. The protein has a calculated MW of 81.6 kDa (α chain 53.7 kDa and β chain 27.9 kDa). The protein migrates as 80-90kDa (alpha & Beta chain), 58-63 (alpha chain), 33 kDa (Beta chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
