Background：Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells.
IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases.
Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms.
High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仕様
サイズ：25ug
Source：Biotinylated Human IL17A, His,Avitag (ILA-H82Q1) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (Accession # Q16552-1).
Molecule：IL-17A
Synonyms：IL-17A,Interleukin-17A,CTLA-8,IL-17
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gly 24 - Ala 155
Conjugate：Precision Avi
Accession：NP_002181.1
Molecular Weight：17.8 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 17.8 kDa. The protein migrates as 19-21 kDa and 23-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
