Background：Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling.
Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner.
Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
仕様
サイズ：25ug
Source：Biotinylated Human IL-23 R, Fc,Avitag (ILR-H82F3) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).
Molecule：IL-23R
Synonyms：IL-23 R,IL-23 Receptor
Species：Human
Tag：Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gly 24 - Gly 355
Conjugate：Precision Avi
Accession：NP_653302.2
Molecular Weight：66.3 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 66.3 kDa. The protein migrates as 95-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
