Background：Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation.
IL‑17C binds to IL‑17 RE with high affinity and to IL‑17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE.
Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways.
Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.
仕様
サイズ：100ug
Source：Human IL-17C, His Tag (ILC-H52H7) is expressed from human 293 cells (HEK293). It contains AA His 19 - Val 197 (Accession # Q9P0M4-1).
Molecule：IL-17C
Synonyms：IL-17C,Cytokine CX2,IL17C
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：His 19 - Val 197
Conjugate：Unconjugated
Accession：NP_037410.1
Molecular Weight：21.6 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.6 kDa. The protein migrates as 24-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
