Background：Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily.
GHR contains one fibronectin type-III domain.
GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle.
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE.
GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
仕様
サイズ：100ug
Source：Rhesus macaque GHR, Fc Tag (GHR-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Tyr 264 (Accession # P79194-1).
Molecule：Growth Hormone R
Synonyms：GHR,GHBP,GH receptor
Species：Rhesus macaque
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Phe 19 - Tyr 264
Conjugate：Unconjugated
Accession：NP_001036132.1
Molecular Weight：54.7 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.7 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>90% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
