Background：GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha.
Low affinity receptor for granulocyte-macrophage colony-stimulating factor.
Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.
仕様
サイズ：100ug
Source：Human GM-CSF R alpha, His Tag (GRA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 320 (Accession # P15509-1).
Molecule：GM-CSF R alpha
Synonyms：GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Glu 23 - Gly 320
Conjugate：Unconjugated
Accession：NP_006131.2
Molecular Weight：36.4 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.4 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
