Background：Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses.
IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.
IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP.
IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
仕様
サイズ：50ug
Source：Human IL-22, His Tag (IL2-H524a) is expressed from human 293 cells (HEK293). It contains AA Ala 34 - Ile 179 (Accession # Q9GZX6-1).
Molecule：IL-22
Synonyms：IL-22,IL-TIF,ZCYTO18
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ala 34 - Ile 179
Conjugate：Unconjugated
Accession：NP_065386.1
Molecular Weight：18.6 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
