Background：Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family.
TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS).
TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation.
TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells.
TNFSF18 also mediates activation of NF-kappa-B.
仕様
サイズ：100ug
Source：Human GITR Ligand, His Tag (GIL-H5249) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).
Molecule：GITR Ligand
Synonyms：TNFSF18,AITRL,TL6,hGITRL,GITR Ligand
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 50 - Ser 177
Conjugate：Unconjugated
Molecular Weight：20.5 kDa
Characteristics：This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.5 kDa. The protein migrates as 23 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
