86-7928-03　［取扱停止］Human Flt-3 Ligand Protein, His Tag 50ug　FLL-H5223

特徴

• Background：FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.
• FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts.
• Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates.
• FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1).
• FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors.
• It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.
• FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation.
• FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation.
• Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation.
• FLT3LG is crucial for steady-state pDC and cDC development.
• A lack of FLT3L results in low levels of DCs.