Background：Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family.
Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)).
Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells.
The IL-21R is widely distributed on lympho-haematopoietic cells.
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.
Its action generally enhances antigen-specific responses of immune cells.
IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.
IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15.
The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
仕様
サイズ：100ug
Source：Human IL-21, Fc Tag (IL1-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1).
Molecule：IL-21
Synonyms：IL21,Za11,Interleukin-21
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Gln 30 - Ser 162
Conjugate：Unconjugated
Accession：NP_068575.1
Molecular Weight：41.9 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.9 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
