Background：Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region.
And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels.
DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors.
Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors.
Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1.
DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
仕様
サイズ：50ug
Source：Mouse Dkk-3, His Tag (DK3-M5226) is expressed from human 293 cells (HEK293). It contains AA Pro 23 - Ile 349 (Accession # NP_056629.1).
Molecule：Dkk-3
Synonyms：DKK3,REIC,RIG
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Pro 23 - Ile 349
Conjugate：Unconjugated
Accession：NP_056629.1
Molecular Weight：37.1 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
