86-7927-40　［取扱停止］Mouse B7-2 / CD86 Protein, Fc Tag (MALS verified) 100ug　CD6-M5251

特徴

• Background：Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
• Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ.
• CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation).
• CD86 works in tandem with CD80 to prime T cells.
• Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival.
• Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages.
• CD86 thus is regarded as a promising candidate for immune therapy.
• CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.