Background：Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily.
GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
仕様
サイズ：25ug
Source：Biotinylated Human GITR, Fc,Avitag (GIR-H82F7) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Molecule：GITR
Synonyms：AITR,GITR,TNFRSF18,CD357
Species：Human
Tag：Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gln 26 - Glu 161
Conjugate：Precision Avi
Accession：NP_004186.1
Molecular Weight：43.3 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 43.3 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
